Recommended by skincare pros & 500k+ customers
Professional-grade micro-infusion, made for your bathroom counter. Smoother, plumper-looking skin in a few minutes a week — or your money back.*
❦ Clinicians' Choice ❦
1,140 clinicians, including dermatologists, share this on FrontrowMD without compensation.
Frequently Asked
Each session pairs a fresh, single-use applicator head lined with ultra-fine micro-points with a serum vial rich in peptides and hyaluronic acid. As you glide the head across your skin, the micro-points create tiny, temporary pathways that help the serum absorb far better than a cream alone. Session after session, skin looks smoother, firmer and more even.
Most people are surprised by how gentle it feels: think a light, prickly tingle rather than pain. Any pinkness typically settles within a few hours, so an evening session fits easily into your routine.
Anywhere you'd like to target visible signs of aging: forehead, around the eyes (never on the eyelids), cheeks, smile lines, upper lip, jawline, neck and chest. Stick to one session every two weeks per area for a smoother, fresher look over time.
One session = one applicator head + one serum vial. Heads are single-use: dispose of each one after your session to keep things hygienic.
We stand behind every kit. Follow the routine for 90 days, and if you're not seeing a visible difference, reach out and we'll refund your purchase. Full terms are in our Refund Policy.
*Shipping fees are not refundable.
Free shipping on every US order.
Changed your mind? Unopened products in their original packaging can be returned within 30 days of delivery. Details in our Refund Policy.
“After just ONE DAY my skin looks much much healthier. Very excited to see what happens over the next 3 months”
“I haven't completed the entire 3 month protocol but I do see some improvement! I will keep on going!”
“Truly impressed! After using for ONE month I can see a drastic change in my neck area! Hoping that my neck will continue to improve. Will be ordering again and have told several people about this product!”
“I used to hate putting on makeup because it always settled into my mouth lines and lip lines, making them even more noticeable. After using Seranova for close to 3 months... I look amazing again when putting on make up"”
Individual results vary. Testimonials are from verified Serano. customers.
In-office micro-infusion sessions can run hundreds of dollars each. Defaree brings the same concept home, so you can keep up a routine that actually fits your life — and your budget.
Twist open the system, fill it with serum, then close tightly again.
Leave the bottle upside down for 2 minutes so the touchpoints are fully coated with serum.
Gently press onto face, lips, or neck with 50% overlap. Repeat 2–3 passes.
Apply any remaining serum to your face and let it absorb overnight.
Based on a Serano. customer survey
Here's what's inside — and what each one does for your skin.
Draws water into the skin's surface and holds it there, so skin looks fuller, smoother and more supple.
Hexapeptide-8, Tetrapeptide-11 and Tetrapeptide-9 work together to support skin's natural structure for a firmer, bouncier, more resilient look.
A form of vitamin B3 that helps even out the look of tone and texture, minimize the look of pores and reinforce the skin barrier.
A well-studied pair of signal peptides (Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7) that helps visibly reduce fine lines and wrinkles while keeping skin calm.
A classic skin-friendly humectant that keeps skin soft and comfortable and helps prevent moisture loss throughout the day.
Aqua, Glycerin, Niacinamide, Butylene Glycol, Acetyl Glucosamine, Panthenol, Trehalose, Sodium PCA, Hydroxyacetophenone, Mannitol, 1,2-Hexanediol, Arginine, Carbomer, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Sodium Lactate, Ergothioneine, Sodium Hyaluronate, Acetyl Hexapeptide-8, Acetyl Tetrapeptide-11, Acetyl Tetrapeptide-9, Ethylhexylglycerin
Science, dermatologists and 500,000+ of customers agree: our products deliver results. That’s why we are confident enough to offer a 90 day results or money back guarantee. If you don’t see visible results, we’ll refund your purchase!
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Every session uses one sterile, single-use applicator head and one serum vial, once every 2 weeks.
Throw the head away after each session.
No. Each head is sterile and built for a single session. Reusing one compromises hygiene and blunts the micro-points, so the next session won't work as well. Bin it once you're done.
Right after your first session, skin usually feels softer and more hydrated. For a visible change in fine lines and texture, plan on 4 to 6 sessions (about 3 months) at the every-2-weeks rhythm. Sticking to the routine is what makes the difference.
Adults who want to target visible signs of aging: fine lines, wrinkles, dullness, uneven texture or dark spots. Collagen naturally declines with age, so many people start in their mid-20s and keep going for years.
Skip it if you have active acne, eczema or psoriasis flare-ups, open wounds or a skin infection, and check with your doctor if you're pregnant or breastfeeding.
Yes, it's designed for every skin type, sensitive skin included. Do a quick patch test first, and if you have a diagnosed skin condition, ask your dermatologist before starting.
Eyes: yes on crow's feet and under-eye lines, but stay about 3 cm (1.5 in) away from the eyelids and waterline.
Lips: a few light presses help with hydration and the look of fine lip lines.
Neck and chest: yes, with lighter strokes since the skin is thinner there.
Little to none. You may see mild pinkness or feel some sensitivity, which usually fades within a few hours (occasionally up to a day). For the next 24 hours, skip makeup, direct sun and harsh skincare.
Gentle, hydrating products like a hyaluronic acid cream or a simple moisturizer are great that same evening.
Pause retinol, glycolic or salicylic acid and vitamin C for 24 to 48 hours so your skin can settle first.
Yes, every kit is covered. Follow the routine for 90 days (reordering as needed), take a photo once a month, and if you don't see a visible improvement, contact us for a refund. Full terms in our Refund Policy.
It targets the look of fine lines, wrinkles, uneven texture, dark spots and loss of firmness. With one session every 2 weeks, skin looks smoother, firmer and fresher over time.
Not at all. A session takes about 10 minutes: attach the serum vial, prime the applicator, then glide it over your face or neck. A step-by-step guide comes with every order.
Yes, just wait at least 2 weeks after your injections so the product can settle. If in doubt, check with your injector.
The key actives are Matrixyl 3000™ peptides (Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7), a peptide complex (Acetyl Hexapeptide-8, Tetrapeptide-11, Tetrapeptide-9), sodium hyaluronate, niacinamide, glycerin, panthenol and ergothioneine. The full ingredient list is in the Ingredients section above.
We don't recommend it. The included serum's formula and texture are matched to the applicator, and other products may not be sterile or may irritate freshly treated skin.
Yes, with some spacing. Leave at least 2 weeks between a session and treatments like peels, laser or professional microneedling, and ask your practitioner if you're unsure.
Yes. One vial comfortably covers the face and neck, and you'll usually have a little left over. Press the extra into your skin at the end of the session.
Yes. The micro-points work at the skin's surface, so it's suitable for every skin tone. Start gently, follow the guide, and if you're prone to hyperpigmentation, wear SPF daily and check with a dermatologist first.
